Germany, 1589: the townspeople of Cologne pronounce a sentence of death on a mass-murderer who has stalked the countryside in the guise of a ferocious wolf.

Russia, 1812: retreating from Napoleon's invading forces, a merchant's daughter is rescued from bandits by a handsome Parisan with a ravenous appetite.

Brazil, 2080: the Doc and Turlough arrive for the Rio de Janeiro carnival. Is wealthy heiress Ileana de Santos all that she seems? What sinister ailment afflicts her invalid son, tended by the mysterious Dr Hayashi? And who exactly is Rosa, engaged on a secret quest to fulfil the destiny of her extinct tribe?

Time is running out for Rosa, Ileana and the Doc, as the fearsome shadow of ancient werewolf moves ever closer...