Touted as the next great family drama, Brothers And Sisters explores the highs and lows of The Walkers - a postmodern American family and their delicate relationships. The series features Sally Field (Norman Rae), Tom Skerritt (Picket Fences), Rachel Griffiths (Six Feet Under), Calista Flockhart (Ally McBeal) and Rob Lowe (The West Wing).

William (Skerritt) and Nora (Field) have raised five unique children, all battling complex problems. Kitty (Flockhart) is an outspoken political commentator who begins a relationship with charismatic Senator Robert McCallister (Lowe), while Sarah (Griffiths) balances motherhood with managing the struggling family business. Tommy (Balthazar Getty) is the loyal son who manages the Walker family business with Sarah. Kevin (Matthew Rhys) is a gay lawyer coming to terms with his sexuality, while Justin (Dave Annable), a veteran of the war in Afghanistan, battles drug addiction.