This show will have anyone laughing from the start. if you're familiar with the Pilkington/Gervais/Merchant trio (and I'm putting Pilkington first on purpose) then you will know what sort of person Karl Pilkington is, if you're not familiar with them then I'd recommend getting the podcasts/audiobooks or watching The Ricky Gervais Show (which is an animated version of the original podcasts).
The show follows Karl Pilkington, a round-headed Manc feller who has a really obscure outlook on everything. It's not fair to call him stupid because he's clever in his own way, so things that happen to him and things that he says during the show are genuinely hilarious because he's not being offensive, he just doesn't know any better.
If you're into slapstick comedy, this isn't for you. If you're into watching a funny funny man travel to the seven wonders (with a head like an orange), this is right up your street.