Manni (Moritz Bleibtreu), who works as a small-time courier for a big-time gangster, is in huge trouble. He has accidentally left the cash from a mob deal on the subway, and he has only twenty minutes to deliver the 100,000 marks to his unforgiving boss.

Desperate, he calls his girlfriend, Lola (Franka Potente), the only person who can rescue him from certain death.

As the seconds tick away and the tiniest choices become life altering, Lola must try to reach Manni before the line between fate and fortune begins to blur. One story told from three different perspectives, Run Lola Run is a veritable maze of intriguing plot twists and heart-stopping suspense in a high-octane thrill ride about one woman's desperate attempt to save her lover.