Fuelled with teenage testosterone and beer, college buddies Josh & Sam are on their way to the annual New Orleans Mardi Gras, for what they believe will be a week in party heaven.

But things get a little crazy long before they reach their destination. After running over and killing an escaped fugitive, the local sheriff mistakes them for a pair of local drug traffickers. Will they reach their destination intact? or will the road trip of a lifetime turn into the comic nightmare of all time?