April Burns (Holmes) is the black sheep of her family who has left suburbia for a Lower East Side tenement. To reconnect with her mother, Joy (Patricia Clarkson), and father, Jim (Oliver Platt), she invites them and her wisecracking brother (John Gallagher Jr.) and perfect sister (Alison Pill) for Thanksgiving dinner at her apartment, and against their better judgment, the Burnses pile up in the family station wagon, pick up Grandma (Alice Drummond), and head to the big city from the safe confines of their stereotypical suburban home. But Joy is seriously ill, complicating the road trip; meanwhile, April's oven is broken, sending her off to her bizarre and wacky neighbors to try to borrow their kitchen.