Edward Douglas(David Thewlis) narrowly escapes death when his plane crashes in the South Pacific. Adrift for weeks, he is rescued and taken to the mysterious island of Dr Moreau (Marlon Brando). Douglas meets the infamous doctor and his enigmatic assistant, Montgomery (Val Kilmer) but finds that he is a prisoner on the island. Unable to leave or get answers about the experiments Dr Moreau is conducting, Douglas searches for answers on his own.

He discovers the beautiful Aissa and becomes infatuated by her animal sensuality. But as he explores further, Douglas uncovers fantastic and brutal experiments turning animal life into human-like beasts. Dr Moreau has used the key of science to unlock the gates of hell.