Leaving their hometown of Fulchester in the North of England, Sandra and Tracey head for the bright lights of London, shagging and boozing their way to fame and fortune. Sean Cooley, an internationally renowned billionaire, suffers a blow to the head, rendering him temporarily insane on the day the Fat Slags arrive in London. Spotting them on a popular daytime TV chat show, he falls in love with their larger than life look and approach!

Determined to make them stars, he forces fashion designer Fidor Constantin to base his next collection around the girls, creating a media sensation. In a whirlwind turn of events, Sandra and Tracey take the UK by storm, hitting number one in the record charts and inadvertently winning the Horner Art Prize. Through their journey into the world of celebrity, jealousy divides a wedge between Sandra and Tracey as they both vie for the attentions of Cooley. Only when he regains his mental faculties and turns on our unlikely heroines, do they realise that friendship is the only real thing they have in this mad world...