August 18, Horn Island. The peace and quiet of a tiny tropical South Pacific island is shattered when a covert scientific-military research operation goes horribly wrong. The only survivors include the scientist behind the formula and the now disgraced officer in charge - the former out to protect the world from his creation and the latter out for revenge.

Ten years later, two young men find themselves in the wrong place at the wrong time when Tim Mason (Skeet Ulrich) and Arlo (Cuba Gooding Jr.) are entrusted with the volatile chemical substance. Unfortunately, Major Brynner and his team are bent on retrieving the lethal substance. He has waited patiently for 10 years for retribution and isn't about to let a couple of amateurs stop him...