Life in prison is the dismal future faced by "White Girl", a career criminal who specializes in armed robbery, often posing as a prostitute. Her cell-mate, Cyclona, is a psychotic young lesbian who is about to do life for murder. Cyclona develops a strong passion for White Girl which goes unreciprocated until the two girls manage to break out of prison.

On the run, Cyclona reveals a horrifying secret about the victims of her murder conviction. Shocked by what she hears, White Girl realizes she's in the company of a serial killer who is following the call of her hallucinatory visions and signs sent from hell, but is in no position to cope on her own, having been wounded in the escape.

In a race for their lives, these two desperados tear across the States, leaving a trail of mayhem and chaos on their bizarre road-trip to Mexico.