No amount of praise can do this programme justice.
The Wire may start off a little slow for some people, but after a few episodes you will start to get hooked. The characters are excellent, and once you get to the 3rd season you'll realise just how deep they are. Many of the more "hood" characters are so far from what you may initially see as stereotypical shells, it really makes you think.
All 5 seasons are interwoven in multiple ways, and characters persist throughout, new ones working their way in, old faces taking varying routes 'out', but all with the same brilliant acting and believable story.
It is different from a lot of shows in that is gives you all sides of the stories, literally in some cases, and is pretty much the best show I have ever watched, recieves a tonne of praise, yet is still underrrated. Give it a deserving viewing and you will not regret it.