I certainly think so. In terms of size, such a huge map, so many different places to explore, but places are still so familiar from GTA IV, fantastic art style and animation, story's a little weak, but that can be forgiven, what with everything else you can do in this game. All of the side missions that were missing from GTA IV are back. I was particularly pleased to see rampages again. I still haven't completed this game 100%, and probably never will.
Absolutely the best game on a handheld ever.