This drive is superb in every way. Compatible with XP, Vista and 7 (not tried any other OS's unfortunately), as well as the Nintendo Wii.
Note that it requires a mains power connection unlike some external hard drives, however as a "desktop" drive this is to be expected.
The drive will automatically power up and down with your PC, meaning that you can leave it plugged in and never need to worry about turning it on and off. The only issue I have with this feature is that if your PC is on and you have a power cut, when the power comes back on the drive boots up again even though the PC is off... but this isn't exactly a major problem and doesn't stop me giving it 5 stars.
I took this drive with me out to India when I was working there for 4 months, it travelled well in the checked luggage and provided me with hours of entertainment. In fact, I took too much which is testatment to the storage capacity! The drive took everything I threw at it, and is now working perfectly back at home.
I would highly recommend this drive to anyone considering some external storage.