This is VERY small and isn't really for moving about between devices. Once plugged into a USB port, it is automatically ready for you and comes with security essentials on it. Of course, you can delete all this if you do not care about that. The speeds are good and I have not had any issues with the device performance.
For a netbook / laptop / PC, it should pretty much be easy to take out (with a little force). I've tried it on my PlayStation 3 (slim) and it proved to be a bit more difficult to get out, since the case goes over the ports. On the Xbox 360 (slim), I have used it on the back USB ports and if you're using other things with this, you will probably have to take those out in order to pull this out (the back USB ports). I have used common sense and decided not to put it in the front USB ports! Unless you have tiny, strong hands, I suggest not using this for devices with tight enclosures around the USB ports. You are better off getting something a bit larger from the SanDisk range or using this with a USB extender cable.